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Symposium: "From DNA to RNA Synthesis, Processing and Cancer"

 

This scientific symposium is being held to mark the retirement of Professor Jean Beggs, CBE, FRS, FRSE

 

Friday 8th November 2019, University of Edinburgh

 

Confirmed Speakers:

 

DNA Repair, Cell Division and Cancer

Prof David Glover, FRS (University of Cambridge, UK)
Prof Sir David Lane, FRS (A*STAR Singapore)
Prof Steve Jackson, FRS (Gurdon Institute, Cambridge, UK)
Dr Martin Reijns (MRC HUman Genetics Unit, Edinburgh, UK)
 

Biogenesis and Decay of non-coding RNAs

Dr Joanna Kufel (University of Warsaw, Poland)
Prof David Tollervey, FRS (University of Edinburgh, UK)
Prof Joan Steitz, NAS (HHMI, Yale School of Medicine, USA)
 

mRNA: Transcription, Splicing and Chromatin

Prof Reinhard Luhrmann (MPI, Gottingen, Germany)
Dr Isabella Maudlin (University of Oxford, UK)
Prof Jean Beggs, FRS (University of Edinburgh, UK)
Prof Karla Neugebauer (Yale School of Medicine, USA)
 

***Registration will open soon***


 

 

         
 

We study the mechanism of pre-messenger RNA splicing and links to transcription and chromatin.

In most eukaryotic genes the information (or code) in the DNA sequence is interrupted by non-coding regions called "introns". An RNA copy of the gene has to be cut and then spliced back together to remove the introns and produce a continuous "message" with the correct information to produce a protein.

Mistakes in the splicing of the RNA cause serious problems as defective proteins are produced, and this sometimes happens as a consequence of genetic defects or disease. The splicing machinery is highly complex and must be tightly regulated. We aim to understand how the many components assemble to form a functional molecular machine (spliceosome) and how its activity is controlled. We are also interested in observed links between transcription, chromatin and splicing and we have obtained evidence that splicing can affect the progress of transcription. The RNA splicing machinery is highly conserved between yeast and humans. We use yeast as a model organism as many powerful experimental techniques are available and it can provide important insights into splicing in humans.

We are located within the Wellcome Centre for Cell Biology at the University of Edinburgh